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In sepsis, lactate promotes ferroptosis via GPR81-mediated upregulation of methyltransferase like 3 (METTL3), which may mediate ACSL4 mRNA stability via N6-methyladenosine (m6A) modification in pulmonary epithelial cells (82)

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MUC1 and HIF-1alpha signaling crosstalk induces anabolic glucose metabolism to impart gemcitabine resistance to pancreatic cancer

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These findings were interpreted as HHE providing the signal to trigger transcriptional regulation, likely through activation of Nrf2 transcription factor